Stem Cell Anti-Aging Treatment - Why We Age
Aging is a complex biological process in which cells become progressively damaged over time and eventually die. As we age, fewer and fewer cells are replaced, slowly wearing out our bodies. This means that over time the damage accumulated in our bodies will become so immense, that at one point the body will not be able to cope with it - ultimately leading to our death.
Environmental factors such as exposure to sun ("solar radiation"), injuries, smoking, air and water pollution, and genetics contribute to speeding up the process of aging.
Aging affects our skin negatively by disturbing the normal function of skin cells. A majority of diseases are a result of aging. Our skin cells experience enormous amount of damage on a daily basis. They are exposed to constant bombardment of tens of thousands harmful elements each day, causing irregular pigmentation (skin discoloration or hyperpigmentation) and loss of elasticity.
Aging is involved in many other processes as well, such as accumulation of senescent cells, oxidative stress and immune and hormonal system changes. All of these factors contribute to increasing the risk of cancerous diseases.
Effects of ANOVA's reYOUvenation on Anti-Aging
Stem cells can be a keystone solution of future medicine, because they tackle the problem on a cellular level. Expensive beauty creams and cosmetics promise only temporary or superficial solutions to your aging problems. Most of them work by masking the processes of aging on the surface level, but never offer solid solutions to where aging really happens.
Latest research in regenerative science provides concrete evidence that aging actually takes place at the cellular level. Therefore, this is where the process of aging needs to be altered.
If you would like to learn more about Stem Cell Treatment for Anti-Aging, then give us a call.
ANOVA offers novel stem cell-based therapies for Anti-Aging and regeneration. Our treatments are potentially capable of repairing the effects of aging. They act on the cellular level by revitalizing the functions of your body from the inside. Our medical specialists make use of your own stem cells to rejuvenate you by speeding up regenerative processes on a cellular level.
All stem cell-based procedures at ANOVA are personalized and in full accordance with the strict quality standards of Germany and the respective healthcare regulations. The medical diagnostics team at ANOVA will help you obtain a general idea of your body’s current health status by performing the following exams, as necessary for you:
* In-depth medical history
* General physical exam
* Personalized clinical chemistry
(blood and urine)
* Cardio-vascular evaluation
* Whole-body cancer check via MRI
* Virtual colonoscopy
* Low-dose CT of the lungs (smoker)
* MR-mammography, etc.
Relevant external information on Stem Cell-based Therapies:
Park, Byung-Soon, and Won-Serk Kim. "Adipose-Derived Stem Cells and Their Secretory Factors for Skin Aging and Hair Loss." Textbook of Aging Skin (2017): 205-224.
Xu, Dan, and Hidetoshi Tahara. "The role of exosomes and microRNAs in senescence and aging." Advanced drug delivery reviews 65.3 (2013): 368-375.
Prattichizzo, Francesco, et al. "Exosome-based immunomodulation during aging: a nano-perspective on inflamm-aging." Mechanisms of Ageing and Development (2017).
Basu, Joydeep, and John W. Ludlow. "Exosomes for repair, regeneration and rejuvenation." Expert opinion on biological therapy 16.4 (2016): 489-506.
Park, Byung-Soon, and Won-Serk Kim. "Adipose-derived stem cells and their secretory factors for skin aging." Textbook of Aging Skin. Springer Berlin Heidelberg, 2010. 201-212.
Soto-Gamez, A., & Demaria, M. (2017). Therapeutic interventions for aging: the case of cellular senescence. Drug Discovery Today.
Moiseeva, O. et al. (2013) Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-kB activation. Aging Cell 12, 489–498.
Martin-Montalvo, A. et al. (2013) Metformin improves healthspan and lifespan in mice. Nat. Commun. 4, 2192.
Pitozzi, V. et al. (2013) Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblasts. J. Gerontol. A Biol. Sci. Med. Sci. 68, 371–381.
Lim, H. et al. (2015) Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts. Biochem. Pharmacol. 96, 337–348.
Toso, A. et al. (2015) Enhancing chemotherapy efficacy by reprogramming the senescence-associated secretory phenotype of prostate tumors: a way to reactivate the antitumor immunity. Oncoimmunology 4, e994380.
Xu, M. et al. (2015) Targeting senescent cells enhances adipogenesis and metabolic function in old age. eLife 4, e12997.
Liou, C.J. et al. (2014) Oral lovastatin attenuates airway inflammation and mucus secretion in ovalbumin-induced murine model of asthma. Allergy Asthma Immunol. Res. 6, 548–557.
Mian, B.M. et al. (2003) Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB. Clin. Cancer Res. 9, 3167–3175.
Karkera, J. et al. (2011) The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a Phase I study. Prostate 71, 1455–1465.
Pellegrini, G. et al. (2004) Telomerase activity is sufficient to bypass replicative senescence in human limbal and conjunctival but not corneal keratinocytes. Eur. J. Cell Biol. 83, 691–700.
Abad, M. et al. (2013) Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature 502, 340–345.
Sagiv, A. et al. (2013) Granule exocytosis mediates immune surveillance of senescent cells. Oncogene 32, 1971–1977.
Demaria, M. et al. (2014) An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev. Cell 31, 722–733.
Pei, Ming. "Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential." Biomaterials (2016).
Vañó-Galván, S., and F. Camacho. "New Treatments for Hair Loss." Actas Dermo-Sifiliográficas (English Edition) (2017).
Anitua, Eduardo, Ander Pino, and Gorka Orive. "Opening new horizons in regenerative dermatology using platelet‐based autologous therapies." International journal of dermatology 56.3 (2017): 247-251.