Stem Cell-based Therapy for

Knee Injuries and Degeneration

Stem Cell-based Therapy for Knee Injuries and Degeneration

Both knee injuries and knee degeneration are frequently reported conditions, and have very limited effective therapy options. Regenerative and cellular therapies for knee pain are urgently needed, both for the treatment of knee injuries, and age-related degenerative knee problems. Treatment of problems related to the knee are among the most applied and researched fields for stem cell-based therapies.

ANOVA offers a unique program with Stem Cell Secretome in combination with Bone Marrow Concentrate Stem Cell injections. Our therapy programs are based on your individual needs and designed for your optimal regenerative effect. Our German Stem Cell Clinic in the heart of Europe offers easy access to patients from all over the world. Contact us today to find out more about your treatment options.


Regeneration of Knee Injuries with Stem Cells: 
Get back to your activities faster, without Surgery

knee picture1

Knee operations should always be considered as the last option for treatment, after the careful review of the results obtained from diagnostics, and after all conventional and regenerative options have been exceeded. Many studies have shown significant improvement of knee function and reduction of pain with the use of stem cell-based therapies. For more information please see references section below.

As with any type of treatment for the knee, experimental therapy such as stem cell-based therapy cannot promise any success. Before the attending physician can suggest an experimental therapy, each case needs to be individually and carefully evaluated. For instance, in some cases an operation in combination with a stem cell treatment might be the better solution. ANOVA offers the newest and highly advanced stem cell treatment options. At the same time, we ensure that your individual needs are being considered, the benefits outweigh the risks and that the therapy aims for your perfect outcome.

For more information of how stem cells can aid you in treating your knee injury, simply contact us today.


Stem Cell treatments for Knee Injuries,
Chronic Syndromes and Degeneration

  • Knee Arthritis
    Knee Arthritis
  • Pes anserine bursitis
    Pes anserine bursitis
  • Baker’s cyst
    Baker’s cyst
  • Biceps Femoris Insertional Tendinopathy
    Biceps Femoris Insertional Tendinopathy
  • Knee Instability
    Knee Instability
  • Patellofemoral Syndrome
    Patellofemoral Syndrome
  • * Arthritis
  • * Meniscus Tear
  • * ACL, MCL, PCL or LCL sprain or tear
  • * Patellofemoral Syndrome / Chondomalacia
  • * aPes anserine bursitis, Baker’s cyst and others
  • * Patellar tendonitis, Hamstrings Tendinopathy
  •   and Biceps Femoris Insertional Tendinopathy

Statistics, Common risks & facts about hip and knee replacement surgery

Knee grafic

Why not just have an operation? More and more orthopedic surgeons are becoming careful and hesitant for recommending surgeries to patients, especially when it is a young patient longing to go back to doing what they love. Why? Because the results for many types of knee surgeries are everything but convincing. Here are some results from scientific literature:
  • 95% do not regain normal activity level through hip replacementi
  • 80% of knee replacement patients do not report an improvement of >15%ii
  • 54% experience pain five years after knee replacement surgeryiii
  • 60% of knee replacement surgeries have no clear medical indicationiv
  • 27% of hip-replacement patients still feel pain several years after surgeryv
  • 47% of knee replacement patient take pain medications during the year following their
  • 4% increase in hip fracture risk during 10 years following knee replacement surgeryvii
  • 200% and 600% increased risk of stomach bleeding following knee and hip replacement retrospectively.viii
  • 3100% increase in risk of heart attack in the two weeks after knee replacement.ix
  • 2600% increase in risk of heart attack in the two weeks after hip replacement.v
  • MRI, the most valuable diagnostic tool in orthopedics, will not be able to determine the cause of pain or injuries in that region anymore due to magnetic interference.
  • Smokers are at extra high risk: +161% Chance of stroke, +53% chance of infection, +34% chance of pneumonia, +63% chance of death at one year post operation.x

This treatment may significantly be enhanced by a therapeutic combination with Infusion Therapy. If you are interested to learn more about the combination therapy, click “I am interested in Infusion Therapy” on our Contact Page.
References and Literature - Stem Cell-based Therapies and Knee Injuries (Click for more)

iKahn, Timothy L., and Ran Schwarzkopf. "Do Total Knee Arthroplasty Patients Have a Higher Activity Level Compared to Patients With Osteoarthritis?." Geriatric Orthopaedic Surgery & Rehabilitation 7.3 (2016): 142-147.

iiSkou, Søren T., et al. "A randomized, controlled trial of total knee replacement." New England Journal of Medicine 373.17 (2015): 1597-1606.

iiiMetsna, Vahur, Sigrid Vorobjov, and Aare Märtson. "Prevalence of anterior knee pain among patients following total knee arthroplasty with nonreplaced patella: a retrospective study of 1778 knees." Medicina 50.2 (2014): 82-86.

ivRiddle, Daniel L., William A. Jiranek, and Curtis W. Hayes. "Use of a validated algorithm to judge the appropriateness of total knee arthroplasty in the United States: a multicenter longitudinal cohort study." Arthritis & Rheumatology 66.8 (2014): 2134-2143.

vWylde, Vikki, et al. "Persistent pain after joint replacement: prevalence, sensory qualities, and postoperative determinants." PAIN® 152.3 (2011): 566-572.

viFuzier, Régis, et al. "Analgesic drug consumption increases after knee arthroplasty: a pharmacoepidemiological study investigating postoperative pain." PAIN® 155.7 (2014): 1339-1345.

viiInternational Osteoporosis  Foundation

viiiLalmohamed, Arief, et al. "Changes in mortality patterns following total hip or knee arthroplasty over the past two decades: a nationwide cohort study." Arthritis & Rheumatology 66.2 (2014): 311-318.

ixLalmohamed, Arief, et al. "Timing of acute myocardial infarction in patients undergoing total hip or knee replacement: a nationwide cohort study." Archives of internal medicine 172.16 (2012): 1229-1235.

xSingh, Jasvinder A., et al. "Smoking as a risk factor for short‐term outcomes following primary total hip and total knee replacement in veterans." Arthritis care & research 63.10 (2011): 1365-1374.

xiHoudek MT. Mesenchymal stem cell therapy for osteoarthritis : current perspectives. 2015:117-124.

xiiTang J, Cui W, Song F, Zhai C. Effects of mesenchymal stem cells on interleukin-1 β -treated chondrocytes and cartilage in a rat osteoarthritic model. 2015:1753-1760. doi:10.3892/mmr.2015.3645.

xiiiMazor M, Lespessailles E, Coursier R. Mesenchymal stem-cell potential in cartilage repair : an update Osteoarthritis. 2014;18(12):2340-2350. doi:10.1111/jcmm.12378.

xivSong F, Tang J, Geng R, et al. Comparison of the efficacy of bone marrow mononuclear cells and bone mesenchymal stem cells in the treatment of osteoarthritis in a sheep model. 2014;7(4):1415-1426.

xvHam O, Lee CY, Kim R, et al. Therapeutic Potential of Differentiated Mesenchymal Stem Cells for Treatment of Osteoarthritis. 2015;(April):14961-14978. doi:10.3390/ijms160714961.

xviKristjánsson B, Honsawek S. Current Perspectives in Mesenchymal Stem Cell Therapies for Osteoarthritis. 2014;2014. doi:10.1155/2014/194318.

xviiCenteno, Christopher, et al. "Efficacy of autologous bone marrow concentrate for knee osteoarthritis with and without adipose graft." BioMed research international 2014 (2014).

xviiiToh WS, Foldager CB, Pei M. Advances in Mesenchymal Stem Cell-based Strategies for Cartilage Repair and Regeneration. Stem Cell Rev Rep. 2014;10:686-696. doi:10.1007/s12015-014-9526-z.

xixCenteno, Christopher J., et al. "Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells, platelet lysate and dexamethasone." Annals of Transplantation 9 (2008): 246-251.

Orozco, Lluis, et al. "Treatment of knee osteoarthritis with autologous mesenchymal stem cells: two-year follow-up results." Transplantation 97.11 (2014): e66-e68.

Filardo, Giuseppe, et al. "Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics." Knee surgery, sports traumatology, arthroscopy 21.8 (2013): 1717-1729.

Jo, Chris Hyunchul, et al. "Intra‐articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof‐of‐concept clinical trial." Stem cells 32.5 (2014): 1254-1266.

Vangsness, C. Thomas, et al. "Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy." J Bone Joint Surg Am 96.2 (2014): 90-98.

Patient Services at ANOVA Institute for Regenerative Medicine

Located in the center of Germany, quick access by car or train from anywhere in Europe

Simple access worldwide, less than 20 minutes from Frankfurt Airport

Individualized therapy with state-of-the-art stem cell products

Individually planned diagnostic work-up which include world-class MRI and CT scans

German high quality standard on safety and quality assurance

Personal service with friendly, dedicated Patient Care Managers

Scientific collaborations with academic institutions to assure you the latest regenerative medical programs