Stem Cell-based Therapies for Lyme Disease

Stem Cell-based Therapies for Lyme Disease

Lyme Disease (LD) can potentially affect everyone, since it is transmitted by ticks which live in our temperate latitudes. It is a disease with many faces and can be associated with various symptoms, making the disease difficult to diagnose.

In most cases, as soon as the disease is detected, a therapy with antibiotics is enough to cure the symptoms without residual impairments. But in some cases, especially if LD is diagnosed in progressive stages or in case of a chronic LD, an antibiotic therapy is insufficient and leaves the patient in pain or paresis.

An encouraging approach in treating LD are Stem Cell-based therapies, especially for patients who do not benefit from an antibiotic treatment. New studies have shown a significant improvement of the outcome in patients treated with Stem Cell-based therapies for Lyme Disease.

How Stem Cells Can Help Treating Lyme Disease

Recent studies have shown a significant improvement for LD patients treated with Stem Cell-based therapies. While an antibiotic therapy is mostly successful in early stages of the acute form, this treatment is often insufficient in chronic LD, leaving the patients with impairments or pain.

In those studies people with chronic LD regained their balance, appetite and strength and reduced tremor and other neurological symptoms.

Since LD is an inflammatory process, Stem Cell-based therapies can help to reduce the effect on the body, resulting in reduced symptoms and a better treatment outcome, especially when combined with other treatment options.

Treating Lyme Disease at ANOVA

Since LD is a disease with many faces and various symptoms, no patient is like the other. Therefore, no treatment should be like the other. At ANOVA, a German clinic for regenerative medicine, we evaluate the medical history of every patient and develop the therapeutic strategy that is best suited for the patient’s specific symptoms and manifestations.

ANOVA combines state-of-the-art technology with evidence-based effective therapies to treat every patient with a fitting treatment for the most effective outcome. This approach is one of a kind in Europe.

Stem Cell Secretome has anti-inflammatory properties that can help manage LD symptoms and facilitate the healing process of your body. Here you can read more about Stem Cell Secretome.

It should be noted that novel and/or experimental therapies, such as stem cell-based therapy, have not undergone the full clinical evaluation yet. Therefore, the attending physician is obliged to analyse the risks and benefits associated with stem cell therapy for each individual patient and case. If the benefits outweigh the potential risks, the doctor may suggest experimental therapies to the patient. Find out if you are suitable for stem cell therapy by contacting us today.


A Disease with Many Faces

Lyme Disease (LD) or Borreliosis is a disease which can affect many different organs and systems, which makes treatment planning very difficult. It is caused by the bacteria Borrelia burgdorferi, which is transmitted by ticks.

Not all people bitten by an infected tick will get the disease. In most cases the infection is sub-clinical and without, or only with local symptoms. Yet in cases the infection gets disseminated, there is a large range of symptoms a patient may suffer from.

The disease proceeds in three stages. In stage I, which occurs in days to weeks after a bite, 50% of patients notice an itching, a red circle around the bite, the Erythema migrans. In many patients this is the only symptom of the infection and there will not be more manifestations. Sometimes this skin condition is accompanied by fatigue, lymph adenosis, headache, joint pain and fever.

Stage II is the early onset dissemination stage, which occurs weeks to months after the bite. Many patients cannot remember to be bitten by tick or suffering from an erythema, thus sometimes patients notice the infection only in stage II. Stage II comes with different symptoms in different systems. 3-12% of patients with Lyme Borreliosis suffer from an acute neuroborreliosis with Bannwarth-syndrome, which is characterized by severe radicular pain and paresis. Neuroborreliosis may also result in a lymphocyte meningism. Another organ which may be affected by Borreliosis is the heart. This so called Lyme-carditis comes with thoracic pain, dyspnoea and arrythmias.

Stage III is the late disseminated infection and occurs months to years after the bite. The patients suffer from Lyme-arthritis with pain and arthritis in large joints, often in the knees. Also, the neuroborreliosis may occur as a chronic form with progressive encephalitis and impairment of walking, cognition and bladder function.

Lyme disease is a disease with many faces, since it can include none of the mentioned symptoms, only some, or even all of them. Additionally, the outcome of the disease varies from a sub-clinical course, over no remaining symptoms, to significant remaining impairment after the infection. These various faces make the diagnosis and the treatment of Lyme Disease very difficult.

FAQ: Stem Cell-based Therapies for Lyme Disease

What are the causes of Lyme Disease?

Lyme Disease is a disease caused by the bacterium Borrelia burgdorferi. The bacteria are transmitted by ticks (Ixodes) endemic in temperate latitudes of the northern hemisphere. The risk of tick bites is increased during the warm months of March to October. It is important to note that not all people bitten by an infected tick will develop the disease. But still it is important to watch out for the first symptoms of an infection to get early treatment.

Since the bacteria are in the gut of the tick, the risk of an infection increases with the time the tick is attached to the skin. An early removal of the tick is a good prevention of getting LD.

Since there is no vaccination against Borrelia burgdorferi yet, the best prevention is to avoid bites and to remove ticks as soon as possible.

What are the symptoms of Lyme Disease?

As mentioned above, LD comes with various manifestations, depending on the stage. Keeping in mind that every patient is different and the range is wide, it is also important to note that it’s possible to suffer from none of those symptoms to all of them. There are also some symptoms that are rare, but potentially possible, such as hepatitis or conjunctivitis. Nevertheless, there are characteristic symptoms for every stage.

Stage I:

  •  Erythema migrans (most specific)
  • Headache
  • Fatigue
  • Fever
  • Lymphadenosis

Stage II:

  • Acute neuroborreliosis
    • Headache
    • Facial paresis
    • Paresis of limbs
    • Radicular pain, especially during the night
  • Lyme-Carditis
    • Arrythmia
    • Dyspnoea
    • Thoracic pain

Stage III:

  • Lyme-Arthritis
    • Joint pain
    • Swollen joints
    • Fatigue
  • Acrodermatitis chronica atrophicans
    • Progressive erythema on limbs, especially the lower legs
  • Chronic neuroborrelioses
    • Progressive encephalitis
    • Impairment of bladder function, cognition and walking None of these symptoms is proof of Lyme Disease. 

If there is a suspicion on an infection with Borrelia Burgdorferi, a precise diagnostic is urgently needed.

How is Lyme Disease diagnosed?

Important in diagnosing LD is the anamnesis, to evaluate if a tick bite occurred. But even if there is no such incident known, it does not mean it is not LD. Often patients do not remember the bite or did not notice it. If the physicians have the suspicion because of the combination of symptoms, a blood test (sometimes cerebrospinal fluid is also needed) will be performed. The body produces antibodies against Borrelia burgdorferi, which can be detected in the patient’s blood or cerebrospinal fluid. The combination of specific symptoms, no other explanation for the symptoms and a positive antibody-reaction will confirm the diagnosis.

What other treatments are available?

As soon as the diagnosis is confirmed, a therapy with antibiotics is started. Which antibiotic is used depends on the stage and the symptoms of the patient.

Often, the medication will stop the infection and the symptoms will disappear. But sometimes, especially with acute or chronical neuroborreliosis, residuals as paresis are possible and are a large impairment of the patient’s quality of life.

In early stages of LD, the antibiotic therapy will cure the disease without residuals in most cases. But especially in advanced stages the risk of therapy-refractory courses increases.

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