Stem Cell Therapy for Erectile Dysfunction & Impotence

Stem Cell Treatment Program for Erectile Dysfunction

Erectile Dysfunctions (ED) is defined as the reduction of potency and libido. It can have a variety of causes, both physical and psychological. Most frequent reasons are diabetes, smoking, obesity or high blood pressure. Additionally, the effects of aging are partly responsible for impotence and ED.

All age groups of men can suffer from weak penile erections, which renders their sexual intercourse problematic or even impossible. In the previous decade, the so called “PDE-5 inhibitors” medications were shown to be a successful group of drugs that improved the quality of life of many affected men. However, they offer limited help by temporarily overriding the symptoms of impotence and ED.

With recent advancements in stem cell research, promising treatment options have emerged. We at ANOVA, a German Stem Cell Clinic, are the first in Europe to introduce a novel stem cell-based medical treatment approach to treat impotence: The ANOVA Stem Cell Secretome.

Schedule an appointment today for more information on how we treat ED with stem cell-based therapies.

Targeting the Cause of ED With Stem Cell Therapy

Despite the wide range of causes of ED, the common denominator is that until now there were only ways to treat the symptoms. Typical medications to treat Erectile Dysfunction (ED) and impotency are based on a substance group called “PDE-5 inhibitors”. Many other drugs have displayed temporal help against impotence in form of injections or creams. There is no clear answer on which of these ED treatment drugs is the best; as they have different properties and side effects. However, all of these drugs have one thing in common: they do not target the cause and therefore are not a “cure”. Their mode of action is based on temporarily overriding the symptoms of weak or no erections.

Regenerative medicine, and the use stem cells as one of their major tools in treating numerous conditions, allows us for a fundamentally different treatment approach. All causes of erectile dysfunction, except in the case of psychologically induced impotence, have some form of primary or secondary blood or nerve supply problem as their main cause. Stem cell-based regenerative therapies have the potential to promote both, angiogenesis (new growth of blood vessels and blood supply improvement) as well as neurotophy / neuroprotection (new growth and protection of nerve supply of the penis).

While there are some causes of ED which cannot be treated (i.e. psychologically induced ED), new discoveries in regenerative medicine and stem cells may be able to find the solution. However, it should be noted that a therapy success cannot be guaranteed with any type of treatment. Particularly in the case of experimental treatments such as stem cell therapy, the attending physician is obliged to perform a benefit-to-risk analysis for each patient and determine both the benefits and the risks for that particular patient. If the potential benefits outweigh the potential side effects, they may recommend experimental therapy. Find out about your therapeutic options at ANOVA - call us today.

Personalized Erectile Dysfunction Treatment at ANOVA IRM

Reduction of potency, impotence and erectile dysfunction has a wide range of possible causes. A good medical assessment and diagnostic is absolutely essential before creating a personalized treatment plan for your erectile dysfunction. Seldom will a single injection of random stem cells adequately address your erectile problems. ANOVA is in close cooperation with a fully equipped image diagnostic clinic with several MRI scanners, CT, ultrasound and state of the art blood test and doctors of many specialties. We will analyse the cause of your potency or ED problem and create a treatment plan which is optimized for your problem. Established guideline methods, medications, nutrition and life style recommendations will be included in your treatment plan – together with state of the art and safe stem cell based therapies.

Like to know more about Erectile Dysfunction and our treatment options?

Then have a look at our Erectile Dysfunktion Flyer.

What are Stem Cells, why does a Stem Cell therapy for ED work and what is revolutionary about the ANOVA approach to treat ED and Impotence?

Stem cells are cells that possess the ability to divide into many subgroups of cells, and are responsible for many controlling functions in the body through their paracrine communication (growth factors, hormones, cytokines, anti-inflammatory factors, extracellular vesicles, exosomes and microRNA). We have a full length article describing some of the medically relevant properties of stem cells and stem cell derived treatments here.

Over 20 pre-clinical studies have been published so far on different stem cell models and different damage models in animals for ED since 2004. In 2016, two Phase I study results were published for Bone Marrow Concentrate (BMC) and fat derived Mesenchymal Stem Cells (adMSCs). Both the human and animal studies universally showed an improvement with different interpretations of the results. A breakthough study was published by Albersen et al. in 2010 that showed that the effects of stem cell injections cannot be accounted to direct differentiation and adherence of the injected stem cells, but rather from their paracrine substances.

The ANOVA Stem Cell Secretome Therapy as the next generation of stem cell-based therapies entails high concentration of these paracrine substances. It thus offers a new approach for the treatment of erectile dysfunction and impotence. We are the first in Europe to take full advantage of the stem cells and harness their regenerative powers via their secreted biocompounds. With the ANOVA Secretome Therapy in combination with Bone Marrow Concentrate Stem Cells we are able to provide a safe way to use stem cells as a natural, personally tailored, regenerative therapy for the different underlying pathologies of erectile dysfunction and impotence.

References and Literature - Stem Cell-based Therapies and Erectile Dysfunction (Click for more)

  1. Gur, Serap, et al. "Advances in stem cell therapy for erectile dysfunction." Expert opinion on biological therapy just-accepted (2018).
  2. Panda, Arabind. "Stem cell in urology—are we at the cusp of a new era?." Translational Andrology and Urology (2018).
  3. Vakalopoulos, Ioannis, et al. "Stem cell therapy in erectile dysfunction: science fiction or realistic treatment option?." Hormones (2018): 1-6.
  4. Wu, Han, et al. "Nanotechnology-assisted adipose-derived stem cell (ADSC) therapy for erectile dysfunction of cavernous nerve injury: In vivo cell tracking, optimized injection dosage, and functional evaluation." Asian journal of andrology 20.5 (2018): 442.
  5. Matz, Ethan L., et al. "Stem Cell Therapy for Erectile Dysfunction." Sexual medicine reviews (2018).
  6. Shan, H., Chen, F., Zhang, T., He, S., Xu, L., & Wei, A. (2015). Stem cell therapy for erectile dysfunction of cavernous nerve injury rats: A systematic review and meta-analysis. PLoS ONE, 10(4), 1–23.
  7. You, Dalsan, et al. "Comparative Study of Autologous Stromal Vascular Fraction and Adipose‐Derived Stem Cells for Erectile Function Recovery in a Rat Model of Cavernous Nerve Injury." Stem cells translational medicine 4.4 (2015): 351-358.
  8. Chen, X., Yang, Q., Zheng, T., Bian, J., Sun, X., Shi, Y., … Deng, C. (2016). Neurotrophic Effect of Adipose Tissue-Derived Stem Cells on Erectile Function Recovery by Pigment Epithelium-Derived Factor Secretion in a Rat Model of Cavernous Nerve Injury, 2016.
  9. Yiou, R., Hamidou, L., Birebent, B., Bitari, D., Lecorvoisier, P., Contremoulins, I., … Rouard, H. (2016). Safety of Intracavernous Bone Marrow-Mononuclear Cells for Postradical Prostatectomy Erectile Dysfunction: An Open Dose-Escalation Pilot Study. European Urology, 69(6), 988–991.
  10. Wang, X. Y., Liu, C. L., Li, S. D., Xu, Y., Chen, P., Liu, Y., … Yang, M. H. (2015). Hypoxia precondition promotes adipose-derived mesenchymal stem cells based repair of diabetic erectile dysfunction via augmenting angiogenesis and neuroprotection. PLoS ONE, 10(3), 1–18.
  11. Haahr, M. K., Jensen, C. H., Toyserkani, N. M., Andersen, D. C., Damkier, P., S??rensen, J. A., … Sheikh, S. P. (2016). Safety and Potential Effect of a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial. EBioMedicine, 5, 204–210.
  12. Bochinski D, Lin GT, Nunes L, Carrion R, Rahman N, Lin CS, et al. (2004) The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. Bju Int 94: 904–09. PMID: 15476533
  13. Kim Y, de Miguel F, Usiene I, Rahman N, Yoshimura N, Huard J, et al. (2006) Injection of skeletal muscle-derived cells into the penis improves erectile function. Int J Impot Res 18: 329–34. PMID: 16341028
  14. Fall PA, Izikki M, Tu L, Swieb S, Giuliano F, Bernabe J, et al. (2009) Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction. Eur Urol. 2009; 56: 716–25. doi: 10.1016/j.eururo.2008.09.059 PMID: 18922625
  15. Albersen M, Fandel TM, Lin G, Wang G, Banie L, Lin CS, et al. (2010) Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 7: 3331–40. doi: 10.1111/j.1743-6109.2010.01875.x PMID: 20561166
  16. Kendirci M, Trost L, Bakondi B, Whitney MJ, Hellstrom WJ, Spees JL (2010) Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. J Urol 184: 1560–66. doi: 10.1016/j.juro.2010.05.088 PMID: 20728109
  17. Lin G, Qiu X, Fandel T, Banie L, Wang G, Lue TF, et al. (2011) Tracking intracavernously injected adipose-derived stem cells to bone marrow. Int J Impot Res 23: 268–75. doi: 10.1038/ijir.2011.38 PMID: 21796145
  18. Lin G, Albersen M, Harraz AM, Fandel TM, Garcia M, McGrath MH, et al. (2011) Cavernous nerve repair with allogenic adipose matrix and autologous adipose-derived stem cells. Urology 77: 1501–09. Woo JC, Bae WJ, Kim SJ, Kim SD, Sohn DW, Hong SH, et al. (2011) Transplantation of muscle-derived stem cells into the corpus cavernosum restores erectile function in a rat model of cavernous nerve injury.
  19. Korean J Urol 52: 359–63. doi: 10.4111/kju.2011.52.5.359 PMID: 21687398 Fandel TM, Albersen M, Lin G, Qiu X, Ning H, Banie L, et al. (2012) Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury. Eur Urol 61: 201–10. doi: 10.1016/j.eururo.2011.07.061 PMID: 21824718
  20. Kim SJ, Park SH, Sung YC, Kim SW (2012) Effect of mesenchymal stem associated to matrixen on the erectile function in the rat model with bilateral cavernous nerve crushing injury. Int Braz J Urol 38: 833– 41. PMID: 23302404
  21. Kim SJ, Choi SW, Hur KJ, Park SH, Sung YC, Ha YS, et al. (2012) Synergistic effect of mesenchymal stem cells infected with recombinant adenovirus expressing human BDNF on erectile function in a rat model of cavernous nerve injury. Korean J Urol 53: 726–32. doi: 10.4111/kju.2012.53.10.726 PMID: 23136635
  22. Kovanecz I, Rivera S, Nolazco G, Vernet D, Segura D, Gharib S, et al. (2012) Separate or combined treatments with daily sildenafil, molsidomine, or muscle-derived stem cells prevent erectile dysfunction in a rat model of cavernosal nerve damage. J Sex Med 9: 2814–26. doi: 10.1111/j.1743-6109.2012. 02913.x PMID: 22974131
  23. Piao S, Kim IG, Lee JY, Hong SH, Kim SW, Hwang TK, et al. (2012) Therapeutic effect of adipose-derived stem cells and BDNF-immobilized PLGA membrane in a rat model of cavernous nerve injury. J Sex Med 9: 1968–79. doi: 10.1111/j.1743-6109.2012.02760.x PMID: 22642440
  24. Qiu X, Villalta J, Ferretti L, Fandel TM, Albersen M, Lin G, et al. (2012) Effects of intravenous injection of adipose-derived stem cells in a rat model of radiation therapy-induced erectile dysfunction. J Sex Med 9: 1834–41. doi: 10.1111/j.1743-6109.2012.02753.x PMID: 22548750
  25. Albersen M, Fandel TM, Lin G, Wang G, Banie L, Lin CS, et al. (2010) Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 7: 3331–40. doi: 10.1111/j.1743-6109.2010.01875.x PMID: 20561166
  26. Tewari, A., et al. "Technique of traction-free nerve-sparing robotic prostatectomy: delicate tissue handling by real-time penile oxygen monitoring." International journal of impotence research 24.1 (2012): 11.

Patient Services at ANOVA Institute for Regenerative Medicine

Located in the center of Germany, quick access by car or train from anywhere in Europe

Simple access worldwide, less than 20 minutes from Frankfurt Airport

Individualized therapy with state-of-the-art stem cell products

Individually planned diagnostic work-up which include world-class MRI and CT scans

German high quality standard on safety and quality assurance

Personal service with friendly, dedicated Patient Care Managers

Scientific collaborations with academic institutions to assure you the latest regenerative medical programs