How Scientific Research Confirmed the Potential of Mesenchymal
Stem Cells for the Regeneration of Damaged Brain and Spine
How Scientific Research Confirmed the Potential of Mesenchymal Stem Cells for the Regeneration of Damaged Brain and Spine
Scientists have devised clever experiments to investigate the healing potential of stem cells. Since these experiments have to be conducted under controlled conditions, they can only be performed in laboratory animals, such as rats.
In the following simplified summaries of different experiments are shown by which important properties of mesenchymal stem cells were proven.
- Mesenchymal Stem Cells (MSC) have the ability to autonomously migrate to those areas in the body, where they are needed for repair and regeneration, e.g. the brain.
- Mesenchymal Stem Cells (MSC) have the ability to transform into brain cells, both supportive glial cells and actual neurons.
In order to prove this scientists have extracted bone marrow from male rats. The mesenchymal stem cells from the bone marrow carry a Y-chromosome (determining male sex). This Y-chromosome can be used as a marker (green fluorescence). The male bone marrow cells were then injected into the bone marrow of female mice, who do not have a Y-chromosome in their cells (black nucleus). After periods ranging between 3 and 70 days, the researchers then investigated the female rats’ brains. They found both glial cells (star shaped) and neurons (round) containing a Y-chromosome (green fluorescence), proving that they were derived from the male rat’s bone marrow cells.
Eglitis M A, Mezey É. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc Natl Acad Sci USA. 1997;94:4080–4085. *Laboratory of Cell Biology, National Institute of Mental Health, and ‡Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
Mezey et al. Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow. Science 2000;290:1779-1782. NIH
News & Insights
Risikofaktoren einer Arthrose
Arthrose betrifft weltweit Millionen Menschen, und während sie bei älteren Menschen deutlich häufiger auftritt, können auch Menschen unter 60 Jahren von der Krankheit betroffen sein. Zu den gefährdeten Personen zählen Personen mit Übergewicht, mit Knochenmangel und mit Arthrose in der Familienanamnese.
Alternatives to knee surgery
Loud crunching when climbing stairs, chronic pain and constant swelling: osteoarthritis in the knee is a very uncomfortable type of pain. If you suffer from knee problems like the ones described, knee surgery is one option. But is that really always necessary? What therapeutic alternatives are there? In this post, we'll give you a few options that might help with your knee pain.
Stem Cell Secretome for the treatment of ED: A success story
How well does stem cell therapy for erectile dysfunction work? Are clinical results available, and if so, what do they show? In this article, we share some research insights on stem cell therapy for the treatment of erectile dysfunction, and talk about a success story of one of our patients who was treated for ED at ANOVA Institute for Regenerative Medicine.
Can stem cell therapy cure erectile dysfunction?
Erectile dysfunction (ED), also known as impotence, affects nearly half of all men between the ages of 40 and 70 in one way or another. ED is defined as a disease which makes it impossible for a man to have a sufficient erection for sexual intercourse. Naturally, sexual dysfunctions are accompanied with a lot of stress for patients and their partners. In this article, we summarize the causes of ED, common treatments, and how stem cells can help treat the disease in a promising way.
Rejuvenation Therapy – An Overview of Anti-Aging Stem Cell Therapies
Rejuvenation therapy is a form of medical treatment with the focus to halt, alter and even reverse the aging process. While there is currently no scientifically proven way to delay our internal aging processes themselves, there are ways to alter or delay some of the effects we experience as we age. Stem cell therapy is on the rise as a rejuvenation treatment. In this article, we discuss the differences between the various stem cell therapies for anti-aging.